This article examines the theoretical and practical aspects of applying an innovative cluster approach to the organization of physical education lessons. The necessity of moving from the isolated use of individual pedagogical technologies toward the systemic interaction of educational resources, methods, participants, and organizational forms of physical education is substantiated. The content of the cluster approach as applied to physical education lessons is revealed, and its main components and principles are identified. Particular attention is paid to the integration of classroom and extracurricular activities, as well as to interaction among teachers, students, educational institutions, sports organizations, and other social partners. The possibilities of using the cluster model to increase students’ physical activity, motivation, independence, and conscious engagement are considered. A model for organizing physical education lessons based on an innovative cluster is proposed. It includes diagnostic, motivational-target, content-technological, practical-activity, and reflective-evaluative components. It is concluded that the cluster approach makes it possible to create a more holistic and flexible educational environment that integrates students’ physical development with their intellectual, social, and personal activity.