O`PKA SILIDA ALT, AST VA DE RITIS INDEKSINING JIGAR HOLATI BIOMARKERLARI SIFATIDAGI AHAMIYATI

Axmadjonova Xurshidabonu Nasirdin qizi; Muhammadjonova Dildora Baxromjon qizi; Rustamova Shohista Omonjonova

doi:10.5281/zenodo.23495731

14.11.2026

Oʻzbekcha

O`PKA SILIDA ALT, AST VA DE RITIS INDEKSINING JIGAR HOLATI BIOMARKERLARI SIFATIDAGI AHAMIYATI

Published

14.11.2026

Journal

Republican Scientific and Practical Conference on “Innovative Educational Technologies in the Integration of Natural Sciences: Tradition and Modernity”

Issue

“Innovative Educational Technologies in the Integration of Natural Sciences: Tradition and Modernity” Republican Scientific and Practical Conference

Pages

15-17

DOI

10.5281/zenodo.23495731

Authors

Axmadjonova Xurshidabonu Nasirdin qizi , Muhammadjonova Dildora Baxromjon qizi , Rustamova Shohista Omonjonova

Abstract

Tezisda o`pka sili bemorlarida sil dorilari gepatotoksikligini nazorat qilishda alaninaminotransferaza (ALT), aspartataminotransferaza (AST) va AST/ALT nisbati (De Ritis indeksi)ning biomarker sifatidagi biokimyoviy asoslari, piridoksal-5′-fosfat tanqisligining ularga taʼsiri hamda olib borilayotgan tadqiqot yondashuvi va umumiy natijalari yoritilgan.

Keywords

De Ritis indeksi alaninaminotransferaza aspartataminotransferaza biomarker gepatotoksiklik o`pka sili piridoksal-5′-fosfat

Other language versions

Русский

В тезисе рассмотрены биохимические основы использования аланинаминотрансферазы (АЛТ), аспартатаминотрансферазы (АСТ) и соотношения АСТ/АЛТ (коэффициент де Ритиса) в качестве биомаркеров контроля гепатотоксичности противотуберкулёзной терапии, влияние дефицита пиридоксаль-5′-фосфата на эти показатели, а также подход и общие результаты проводимого исследования.

аланинаминотрансфераза аспартатаминотрансфераза биомаркер гепатотоксичность коэффициент де Ритиса мониторинг печени. пиридоксаль-5′-фосфат туберкулёз лёгких

English

The thesis discusses the biochemical basis for using alanine aminotransferase (ALT), aspartate aminotransferase (AST) and the AST/ALT (De Ritis) ratio as biomarkers for monitoring antituberculosis drug hepatotoxicity in patients with pulmonary tuberculosis, the effect of pyridoxal-5′-phosphate deficiency on these markers, and the approach and general findings of the ongoing study.

De Ritis ratio alanine aminotransferase aspartate aminotransferase biomarker hepatotoxicity liver monitoring pulmonary tuberculosis pyridoxal-5′-phosphate

References

1. World Health Organization. Global Tuberculosis Report 2023. Geneva: WHO; 2023.

2. Saukkonen J.J. et al. An official ATS statement: hepatotoxicity of antituberculosis therapy. Am J Respir Crit Care Med. 2006;174(8):935–952.

3. Giannini E.G., Testa R., Savarino V. Liver enzyme alteration: a guide for clinicians. CMAJ. 2005;172(3):367–379.

4. De Ritis F., Coltorti M., Giusti G. An enzymic test for the diagnosis of viral hepatitis: the transaminase serum activities. Clin Chim Acta. 1957;2(1):70–74.

5. Botros M., Sikaris K.A. The De Ritis ratio: the test of time. Clin Biochem Rev. 2013;34(3):117–130.

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